Description

Meperidine (D4) is a deuterated analog of the well-known opioid analgesic, meperidine, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative analytical methods, ensuring the highest accuracy and reliability in mass spectrometry. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and forensic science sectors, enabling precise pharmacokinetic studies, drug metabolism research, and the development of robust analytical assays.

Application

• Internal Standard for LC-MS/MS: Primary application for the quantitative analysis of meperidine in biological matrices (plasma, urine, serum) and pharmaceutical formulations.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in research settings.
• Forensic Toxicology: Used in confirmatory testing and method development for the detection and quantification of meperidine in forensic samples.
• Pharmaceutical Quality Control: Supports assay development and validation for ensuring the potency and purity of meperidine-containing drug products.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and validating testing procedures.
• Isotope Dilution Mass Spectrometry (IDMS): Critical component in this high-precision technique for achieving definitive measurement results.

Basic Information

Product Name	Meperidine (D4)
CAS No.	53484-73-4
Molecular Formula	C15H17D4NO2
Molecular Weight	251.36 g/mol (approx.)
Synonyms	Pethidine-d4; Isonipecaine-d4; Demerol-d4; 1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester-d4; Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate-d4; Lidol-d4; Dolantin-d4; Centralgin-d4
EINECS	Contact for details

Quality Control

Our Meperidine (D4) is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), and identification. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95% (by NMR)
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.