Description

(6R)-3-Chloro-8-Oxo-7α-[(2-Thienylacetyl)Amino]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a high-purity pharmaceutical intermediate and a key structural component in the synthesis of advanced cephalosporin antibiotics. Its precise stereochemistry and functional groups are critical for imparting potent antibacterial activity and β-lactamase stability to the final drug molecules. This compound is essential for research institutions and manufacturers developing next-generation antibacterial agents to combat resistant infections.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of third and fourth-generation cephalosporin antibiotics.
• Antibacterial Drug Development: Used in R&D for creating novel β-lactam antibiotics with enhanced spectra of activity.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core precursor in multi-step manufacturing processes for final API production.
• Biochemical Research: Employed in studies investigating the structure-activity relationship (SAR) of β-lactam compounds and mechanisms of bacterial resistance.
• Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical labs.

Basic Information

Product Name	(6R)-3-Chloro-8-Oxo-7α-[(2-Thienylacetyl)Amino]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	53483-71-9
Molecular Formula	C14H11ClN2O4S2
Molecular Weight	370.83 g/mol
Synonyms	7α-(2-Thienylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 3-Chloro-7α-(2-thienylacetamido)ceph-3-em-4-carboxylic acid; 7-ACA derivative (3-chloro, 7α-thienylacetamido); Cephalosporanic acid derivative; (6R,7R)-3-Chloro-7-[(2-thienylacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (6R)-3-Chloro-8-Oxo-7α-[(2-Thienylacetyl)Amino]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identification via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (6R,7R isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.