Description

4-(Trifluoromethyl)Hydrocinnamic Acid is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of the hydrocinnamic acid backbone with a metabolically stable trifluoromethyl group, which can dramatically alter the physicochemical properties of target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers and compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced thermal stability, chemical resistance, or unique optical properties.
• Chemical Research & Development: Employed as a standard reagent in academic and industrial labs for studying fluorination effects and developing new synthetic methodologies.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid functionality allows for coupling to create fluorinated peptide analogs or for use in linker chemistry for bioconjugation applications.

Basic Information

Product Name	4-(Trifluoromethyl)Hydrocinnamic Acid
CAS No.	53473-36-2
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	3-[4-(Trifluoromethyl)phenyl]propanoic acid; 4-(Trifluoromethyl)benzene propanoic acid; (4-Trifluoromethylphenyl)propionic acid; β-(4-Trifluoromethylphenyl)propionic acid; 3-(4-Trifluoromethylphenyl)propionic acid; 4-(Trifluoromethyl)phenylpropanoic acid; Hydrocinnamic acid, 4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Hydrocinnamic Acid is produced under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (by HPLC), identity (by IR and NMR), and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.