Description

Angiotensin II, Aib(1)- CAS NO 53462-47-8 is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, modified with an aminoisobutyric acid (Aib) substitution at position 1 to enhance its metabolic stability and receptor binding affinity. This modification makes it a critical research tool for studying the renin-angiotensin system (RAS), a key regulator of blood pressure and fluid balance. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and academic institutions engaged in cardiovascular disease research, drug discovery, and biochemical assay development.

Application

• Biomedical Research: Fundamental studies on the renin-angiotensin system (RAS), its receptors (AT1, AT2), and associated signaling pathways.
• Drug Discovery & Screening: Used as a reference standard or agonist in high-throughput screening (HTS) assays to identify and characterize novel antihypertensive or cardiovascular drug candidates.
• Receptor Binding Assays: Essential for competitive binding studies to determine the affinity and potency of new compounds for Angiotensin II receptors.
• In Vitro & Ex Vivo Studies: Investigation of vascular contraction, aldosterone secretion, and other physiological responses mediated by Angiotensin II in tissue or cell culture models.
• Biochemical Tool Development: A key component in developing and validating ELISA kits, radioimmunoassays (RIA), and other diagnostic or research immunoassays.
• Metabolic Stability Studies: Serves as a model peptide to study the effects of Aib substitution on resistance to enzymatic degradation (e.g., by aminopeptidases).

Basic Information

Product Name	Angiotensin II, Aib(1)- CAS NO 53462-47-8
CAS No.	53462-47-8
Molecular Formula	C₅₀H₇₁N₁₃O₁₂
Molecular Weight	1046.2 g/mol
Synonyms	[Aib1]-Angiotensin II; Asp-Arg-Val-Aib-Ile-His-Pro-Phe; H-Asp-Arg-Val-Aib-Ile-His-Pro-Phe-OH; 1-Aminoisobutyric Acid1-Angiotensin II; Angiotensin II (1-8) (human, mouse, rat) Aib1 analog; Aib1-Ang II; ATII Aib(1) analog
EINECS	Contact for details

Quality Control

Our Angiotensin II, Aib(1)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.