Description

1-Amino-3-Fluoropropan-2-Ol Hydrochloride is a versatile fluorinated amino alcohol hydrochloride salt, a key chiral building block in advanced organic synthesis. Its value lies in providing a functionalized scaffold that introduces both fluorine and amino alcohol motifs, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and complex specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the development of fluorinated drug candidates, including protease inhibitors, kinase inhibitors, and antibiotics.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides to enhance efficacy and environmental profile.
• Peptide Mimetics & Modifications: Serves as a building block for introducing fluorinated amino acid analogs into peptides to improve metabolic stability and binding affinity.
• Ligand & Catalyst Development: Employed in the synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers and advanced materials.
• Chemical Biology Probes: Utilized to create fluorinated probes and tool compounds for studying biological mechanisms and enzyme functions.

Basic Information

Product Name	1-Amino-3-Fluoropropan-2-Ol Hydrochloride
CAS No.	53460-74-5
Molecular Formula	C₃H₉ClFNO
Molecular Weight	129.56 g/mol
Synonyms	3-Fluoro-2-hydroxypropylamine hydrochloride; 1-Amino-3-fluoro-2-propanol hydrochloride; 3-Fluoro-2-propanolamine hydrochloride; 2-Propanol, 1-amino-3-fluoro-, hydrochloride; (±)-1-Amino-3-fluoropropan-2-ol hydrochloride; 3-Fluoro-1-aminopropan-2-ol HCl; 1-Amino-3-fluoroisopropanol hydrochloride; FAHP-HCl
EINECS	Contact for details

Quality Control

Our 1-Amino-3-Fluoropropan-2-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) documenting identity, purity (HPLC/GC), and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.