Description

n-Methyl Bromofluoroacetamide is a specialized fluorinated acetamide derivative, serving as a versatile and high-value building block in advanced organic synthesis. Its unique structure, featuring both bromo and fluoro substituents, makes it a critical intermediate for introducing fluorinated motifs into target molecules, which is a key strategy in modern pharmaceutical and agrochemical development. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to enhance the metabolic stability, bioavailability, and binding affinity of their novel compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atom improves biological activity and environmental persistence.
• Fluorinated Material Precursor: Serves as a monomer or modifier in the creation of specialty polymers and advanced materials with unique surface properties or chemical resistance.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the effects of halogenation on molecular interactions and potency.
• Cross-Coupling Reactions: The bromo moiety acts as a handle for various palladium-catalyzed cross-coupling reactions, such as Suzuki or Sonogashira couplings, enabling complex molecule assembly.
• Radiolabeling Precursor: Potential use as a precursor for the synthesis of compounds labeled with fluorine-18 for Positron Emission Tomography (PET) imaging.

Basic Information

Item	Details
Product Name	n-Methyl Bromofluoroacetamide
CAS No.	53441-14-8
Molecular Formula	C3H5BrFNO
Molecular Weight	170.98 g/mol
Synonyms	Bromofluoro-N-methylacetamide; 2-Bromo-2-fluoro-N-methylacetamide; N-Methyl-2-bromo-2-fluoroacetamide; Methylbromofluoroacetamide; Bromofluoroacetmethylamide; Acetamide, 2-bromo-2-fluoro-N-methyl-; α-Bromo-α-fluoro-N-methylacetamide
EINECS	Contact for details

Quality Control

Every batch of n-Methyl Bromofluoroacetamide is manufactured and tested under a strict quality management system to ensure consistency and reliability for your critical synthetic applications. We provide comprehensive analytical data, including HPLC purity, NMR (¹H, ¹³C, ¹⁹F) confirmation, and identity verification by IR spectroscopy. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.