Description

Z-Val-Pro-Oh is a protected dipeptide building block, specifically the C-terminal carboxylic acid of the Z-Val-Pro sequence. This compound is a critical intermediate in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of therapeutic agents and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential assembly of longer peptide chains in both research and GMP manufacturing.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Peptidomimetic Research: Serves as a building block for creating modified peptide analogs with enhanced stability or biological activity.
• Biochemical Research: Employed in studies of enzyme substrates, inhibitors, and protein-protein interactions.
• Custom Peptide Production: Essential for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients.

Basic Information

Product Name	Z-Val-Pro-Oh
CAS No.	53331-43-4
Molecular Formula	C18H24N2O5
Molecular Weight	348.40 g/mol
Synonyms	Z-Val-Pro-OH; N-Cbz-L-Valyl-L-Proline; Benzyloxycarbonyl-L-valyl-L-proline; CBZ-Val-Pro-OH; Nα-Carbobenzoxy-L-valyl-L-proline; L-Valine, N-[(phenylmethoxy)carbonyl]-, 1-L-prolyl-; (S)-2-(((Benzyloxy)carbonyl)amino)-3-methylbutanoyl-L-proline; Z-L-Val-L-Pro-OH
EINECS	Contact for details

Quality Control

Our Z-Val-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	-50° to -55° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.