Description

n-Methyl-2,2-difluoroacetamide is a versatile fluorinated acetamide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoromethyl group adjacent to the amide carbonyl, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of fluorinated drug candidates, including protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Building block for novel herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science: Precursor for specialty polymers and coatings with tailored surface properties and improved chemical resistance.
• Organic Synthesis Reagent: Used in nucleophilic substitution and condensation reactions to introduce the -CHF2 pharmacophore into target molecules.
• Fluorine Chemistry Research: A valuable standard and starting material for studying the effects of gem-difluorination on amide chemistry and reactivity.

Basic Information

Product Name	n-Methyl-2,2-difluoroacetamide
CAS No.	53207-28-6
Molecular Formula	C3H5F2NO
Molecular Weight	109.07 g/mol
Synonyms	2,2-Difluoro-N-methylacetamide; N-Methyl-2,2-difluoroacetamide; N-Methyl-α,α-difluoroacetamide; Methyl(2,2-difluoroacetyl)amine; Acetamide, 2,2-difluoro-N-methyl-; Difluoroacetic acid methylamide
EINECS	Contact for details

Quality Control

Our n-Methyl-2,2-difluoroacetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.