Description

β-Carotene (10,10',19,19,19,19',19',19'-D8, 97%) is a deuterium-labeled analog of the essential pro-vitamin A carotenoid, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity, isotopically labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based analyses, eliminating matrix effects and enabling precise quantification. It is primarily required by analytical laboratories, pharmaceutical R&D teams, and food science researchers engaged in method development, pharmacokinetic studies, and nutritional analysis where trace-level detection of β-carotene is necessary.

Application

• Internal Standard for LC-MS/MS and GC-MS: Serves as a critical reference compound for the accurate quantification of native β-carotene in complex biological and food matrices.
• Pharmacokinetic and Metabolic Tracing Studies: Used in research to track the absorption, distribution, metabolism, and excretion (ADME) of β-carotene in vivo.
• Stable Isotope Dilution Assays (SIDA): Enables highly precise and accurate measurement of β-carotene levels in clinical, nutritional, and pharmaceutical samples.
• Method Development and Validation: Essential for developing robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Food and Nutritional Supplement Analysis: Ensures accurate potency testing and quality control of fortified foods and dietary supplements.
• Biochemical Research: Facilitates studies on antioxidant mechanisms, vitamin A metabolism, and carotenoid pathways.

Basic Information

Product Name	β-Carotene (10,10',19,19,19,19',19',19'-D8, 97%)
CAS No.	53163-44-3
Molecular Formula	C₄₀H₄₈D₈
Molecular Weight	~ 544.9 g/mol
Synonyms	β-Carotene-d8; all-trans-β-Carotene-d8; Deuterated β-Carotene; β,β-Carotene-d8; Vitamin A precursor-d8; Provitamin A-d8; CI 40800 (deuterated); Food Orange 5 (deuterated)
EINECS	Contact for details

Quality Control

Every batch of our deuterated β-Carotene-d8 is produced and analyzed under strict quality protocols to ensure high isotopic purity (97%) and chemical integrity. Our quality system is designed to support GMP/GLP-compliant research. Comprehensive Certificates of Analysis (COA) are provided, detailing results from NMR, HPLC, and MS analyses to confirm identity, chemical purity, isotopic enrichment, and absence of significant impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	Red to reddish-brown crystalline solid or powder
Identification (HPLC/MS)	Conforms to reference standard
Isotopic Purity (D8)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solubility	Soluble in chloroform, DCM; slightly soluble in hexane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.