Description

(2S)-5-Amino-2-(tert-Butoxycarbonylamino)-Pentanoic Acid tert-Butyl Ester is a protected amino acid derivative, specifically a Boc-protected L-ornithine derivative with a tert-butyl ester group. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering orthogonal protection strategies for the side-chain amino and α-carboxyl groups. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs), diagnostic agents, and advanced research biochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the solid-phase and solution-phase synthesis of peptide-based drugs and therapeutic candidates.
• API Synthesis: Used in the construction of complex molecules where selective deprotection of the Boc group and tert-butyl ester is required.
• Bioconjugation & Linker Chemistry: Serves as a precursor for creating specialized linkers and spacers in antibody-drug conjugates (ADCs) and other bioconjugation platforms.
• Research & Development: Essential in academic and industrial laboratories for medicinal chemistry programs targeting various disease pathways.
• Peptidomimetic Design: Facilitates the development of metabolically stable peptide analogs by providing a protected framework for structural modification.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring high-purity chiral intermediates.

Basic Information

Product Name	(2S)-5-Amino-2-(tert-Butoxycarbonylamino)-Pentanoic Acid tert-Butyl Ester
CAS No.	53054-03-8
Molecular Formula	C15H30N2O4
Molecular Weight	302.41 g/mol
Synonyms	Boc-L-Ornithine(OtBu)-OH; Boc-Orn(Boc)-OtBu; (S)-2-((tert-Butoxycarbonyl)amino)-5-((tert-butoxycarbonyl)amino)pentanoic acid tert-butyl ester; Nα,Nδ-Bis-Boc-L-ornithine tert-butyl ester; Nα-Boc-Nδ-Boc-L-ornithine tert-butyl ester; tert-Butyl (2S)-5-[(tert-butoxycarbonyl)amino]-2-[(tert-butoxycarbonyl)amino]pentanoate; L-Ornithine, N2,N5-bis[(1,1-dimethylethoxy)carbonyl]-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our (2S)-5-Amino-2-(tert-Butoxycarbonylamino)-Pentanoic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.