Description

2,3,5,6-Tetrafluorobenzyl Bromide is a versatile fluorinated benzyl bromide derivative, a crucial building block in advanced organic synthesis. Its value lies in its ability to introduce the highly functionalized tetrafluorobenzyl group, enabling the development of compounds with enhanced stability and unique electronic properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors, particularly for creating active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in the development of fluorinated drugs where the tetrafluorobenzyl moiety can improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where fluorination is a common strategy to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, imparting valuable characteristics such as chemical resistance, low surface energy, and thermal stability.
• Cross-Coupling Reactions: Acts as an effective electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl structures common in many functional molecules.
• Ligand & Catalyst Development: Useful for synthesizing novel fluorinated ligands and organocatalysts used in asymmetric synthesis and other specialized catalytic processes.

Basic Information

Product Name	2,3,5,6-Tetrafluorobenzyl Bromide
CAS No.	53001-73-3
Molecular Formula	C7H3BrF4
Molecular Weight	242.99 g/mol
Synonyms	α-Bromo-2,3,5,6-tetrafluorotoluene; (2,3,5,6-Tetrafluorophenyl)methyl Bromide; 2,3,5,6-Tetrafluoro-α-bromotoluene; 2,3,5,6-Tetrafluorobenzylbromide; Perfluorobenzyl Bromide (common, but technically incorrect); TFB-Br; 53001-73-3
EINECS	Contact for details

Quality Control

Our 2,3,5,6-Tetrafluorobenzyl Bromide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.