Description

Benzeneacetic Acid, 4-Fluoro-α-Hydroxy-, (αs)- is a chiral fluorinated derivative of mandelic acid, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in the precise introduction of both fluorine and a stereogenic center, enabling the development of molecules with tailored biological activity and metabolic stability. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of enantiomerically pure active ingredients and complex fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of fluorinated active pharmaceutical ingredients (APIs), including potential anti-inflammatory and CNS-targeting drugs.
• Agrochemical Synthesis: Building block for developing novel, enantiomerically pure herbicides, fungicides, and pesticides with enhanced efficacy and environmental profile.
• Asymmetric Catalysis & Ligand Design: Used in the preparation of chiral ligands and catalysts for stereoselective synthesis.
• Fine Chemical Production: Intermediate for the manufacture of specialty fluorinated aromatics and complex organic molecules.
• Academic & R&D: Valuable reference standard and starting material in medicinal chemistry and process development research.

Basic Information

Product Name	Benzeneacetic Acid, 4-Fluoro-α-Hydroxy-, (αs)-
CAS No.	52923-25-8
Molecular Formula	C8H7FO3
Molecular Weight	170.14 g/mol
Synonyms	(S)-2-Hydroxy-2-(4-fluorophenyl)acetic Acid; (S)-4-Fluoromandelic Acid; (S)-α-Hydroxy-4-fluorobenzeneacetic Acid; L-4-Fluoromandelic Acid; (S)-(-)-4-Fluoromandelic Acid; (S)-2-(4-Fluorophenyl)-2-hydroxyacetic Acid; (αS)-α-Hydroxy-4-fluorobenzenecetic Acid
EINECS	Contact for details

Quality Control

Our production of Benzeneacetic Acid, 4-Fluoro-α-Hydroxy-, (αs)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. We employ advanced analytical techniques, including chiral HPLC, to verify enantiomeric excess and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chiral purity is provided with each shipment, supporting cGMP and ISO standards for intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.