Description

Chenodeoxycholic Acid-24-13C is a stable isotope-labeled analog of the primary human bile acid, where the carbon atom at the 24-position is enriched with the 13C isotope. This precise labeling is critical for applications requiring high specificity and traceability, such as quantitative mass spectrometry and metabolic pathway studies. It is an essential research tool for pharmaceutical developers, clinical diagnostic laboratories, and academic institutions investigating bile acid metabolism, liver function, and related disorders.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for accurate measurement of endogenous chenodeoxycholic acid levels in biological matrices like serum, plasma, and urine.
• Metabolic Tracer Studies: Used in pharmacokinetic and metabolic flux analysis to trace the biosynthesis, distribution, and elimination pathways of bile acids in vivo.
• Drug Development & Biomarker Research: Facilitates the development and validation of assays for drug candidates targeting bile acid receptors (e.g., FXR) and for discovering new biomarkers in hepatobiliary diseases.
• Clinical Diagnostics: Enables precise calibration in diagnostic kits and laboratory-developed tests for conditions such as cholestasis, progressive familial intrahepatic cholestasis (PFIC), and cerebrotendinous xanthomatosis (CTX).
• Quality Control in Pharmaceutical Manufacturing: Employed as a reference material to ensure the purity and consistency of pharmaceutical-grade bile acid products and formulations.

Basic Information

Product Name	Chenodeoxycholic Acid-24-13C
CAS No.	52918-92-0
Molecular Formula	C24H40O4 (with 13C at position 24)
Molecular Weight	~393.6 g/mol (13C labeled)
Synonyms	3α,7α-Dihydroxy-5β-cholan-24-oic-24-13C acid; CDCA-24-13C; 13C-Chenodeoxycholic Acid; (13C)Chenodeoxycholic Acid; 24-13C-Chenodeoxycholic Acid; 5β-Cholan-24-oic-24-13C acid-3α,7α-diol; Chenodiol-24-13C
EINECS	Contact for details

Quality Control

Every batch of our Chenodeoxycholic Acid-24-13C is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR, HPLC, and MS. Certificates of Analysis (COA) are provided with each shipment, detailing assay, isotopic enrichment, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Enrichment	≥ 99 atom % 13C (at position 24)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.