Description

Aldosterone 21-Hemisuccinate is a key hemisuccinate ester derivative of the vital mineralocorticoid hormone aldosterone. This high-purity intermediate is essential for research and development in endocrinology and pharmaceutical synthesis, offering a versatile building block for conjugation and prodrug strategies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic reagents and reference standards.

Application

• Pharmaceutical Intermediate: Critical starting material or conjugate for the synthesis of novel steroid-based therapeutics and prodrugs targeting the mineralocorticoid receptor.
• Biochemical Research: Used as a standard or reagent in studies investigating aldosterone's mechanism of action, receptor binding assays, and metabolic pathways.
• Diagnostic Kit Manufacturing: Serves as a hapten for the development of antibodies used in enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA) kits for aldosterone detection.
• Reference Standard: Employed as a certified reference material (CRM) in analytical laboratories for method validation, quality control, and regulatory compliance testing.
• Conjugation Chemistry: The hemisuccinate group enables covalent attachment to carrier proteins (e.g., BSA) for immunogen production or to other molecules for targeted delivery systems.

Basic Information

Item	Details
Product Name	Aldosterone 21-Hemisuccinate
CAS No.	52910-82-4
Molecular Formula	C27H38O7
Molecular Weight	474.59 g/mol
Synonyms	11β,21-Dihydroxy-3,20-dioxopregn-4-en-18-al 21-Hemisuccinate; Aldosterone 21-Hemisuccinate BSA Conjugate (precursor); 18-Oxocorticosterone 21-Hemisuccinate; Aldosterone-21-hemisuccinate; Aldosterone hemisuccinate; 21-Hemisuccinyloxyaldosterone
EINECS	Contact for details

Quality Control

Our Aldosterone 21-Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) providing batch-specific results is supplied with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.