Description

Cholic Acid-24-13C is a stable isotope-labeled analog of the primary human bile acid, cholic acid, where the carbon atom at the 24-position is enriched with the 13C isotope. This precise labeling makes it an indispensable internal standard and tracer in advanced biomedical research, ensuring unparalleled accuracy in quantitative mass spectrometry analyses. It is critically needed by pharmaceutical R&D teams, clinical research organizations, and academic institutions focused on lipid metabolism, drug development, and biomarker discovery.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the precise quantification of endogenous cholic acid and related bile acids in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of bile acid-based pharmaceuticals.
• Clinical Diagnostics Research: Enables the development and validation of highly accurate assays for diagnosing and monitoring hepatobiliary disorders such as cholestasis and primary biliary cholangitis.
• Metabolic Pathway Analysis: Facilitates the tracing and flux analysis of bile acid synthesis and enterohepatic circulation in in vitro and in vivo models.
• Stable Isotope Dilution Assays (SIDA): Provides the gold-standard methodology for achieving high accuracy and precision in analytical measurements, minimizing matrix effects.
• Biomarker Discovery and Validation: Essential for the reliable identification and quantification of bile acid signatures associated with specific disease states.

Basic Information

Product Name	Cholic Acid-24-13C
CAS No.	52886-36-9
Molecular Formula	C24H40O5 (with 13C at position 24)
Molecular Weight	409.58 g/mol (for 13C labeled form)
Synonyms	24-13C-Cholic Acid; (24-13C)Cholic Acid; 3α,7α,12α-Trihydroxy-5β-cholan-24-oic-24-13C acid; 13C Labeled Cholic Acid; Cholic Acid (24-13C); [24-13C]-Cholic Acid; CA-24-13C; Stable Isotope-Labeled Cholic Acid
EINECS	Contact for details

Quality Control

Our Cholic Acid-24-13C is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥99 atom % 13C), chemical purity (by HPLC), and confirming structural identity. We adhere to cGMP principles for research chemicals, ensuring traceability, consistency, and reliability in every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Chemical Purity (by HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.