Description

3-Ursodeoxycholic Acid-D5 is a deuterium-labeled analog of the primary bile acid ursodeoxycholic acid (UDCA), specifically designed for use as an internal standard in quantitative analytical methods. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, where it corrects for variations in sample preparation and instrument response. It is a critical material for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require precise measurement of UDCA and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable isotope-labeled internal standard for the quantitative bioanalysis of ursodeoxycholic acid in biological matrices (plasma, serum, bile).
• Pharmaceutical R&D: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies during the development of UDCA-based therapeutics.
• Metabolomics Research: Enables precise tracking and quantification of bile acid pathways and metabolism in research studies.
• Clinical Diagnostics: Supports the development and validation of high-precision diagnostic assays for liver function and cholestatic diseases.
• Quality Control & Reference Standard: Serves as a certified reference material for calibrating analytical instruments and verifying assay methods in GMP/GLP environments.

Basic Information

Product Name	3-Ursodeoxycholic Acid-D5
CAS No.	52840-12-7
Molecular Formula	C24H35D5O4
Molecular Weight	395.58 g/mol
Synonyms	UDCA-D5; Ursodiol-D5; 3α,7β-Dihydroxy-5β-cholan-24-oic-3,3,4,4,5-d5 Acid; Ursodeoxycholic Acid-d5; Deoxycholic Acid, 3,3,4,4,5-d5; (3α,5β,7β)-3,7-Dihydroxycholan-24-oic-3,3,4,4,5-d5 Acid; Cholanoic Acid, 3,7-dihydroxy-, (3α,5β,7β)-, labeled with deuterium
EINECS	Contact for details

Quality Control

Our 3-Ursodeoxycholic Acid-D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.