Description

3-Bromo-4-Hydroxy-5-Methoxybenzonitrile is a versatile benzonitrile derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique substitution pattern makes it a valuable building block for constructing complex molecules with specific electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders or possessing kinase inhibitory activity.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and plant growth regulators, leveraging its halogen and nitrile functionalities.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and advanced polymers due to its electron-withdrawing nitrile group and potential for further functionalization.
• Dye and Pigment Chemistry: Intermediate for synthesizing specialized dyes and pigments where the bromo and hydroxy groups allow for color tuning and enhanced stability.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for creating biaryl structures common in many modern chemicals.
• Ligand and Catalyst Development: Useful scaffold for constructing chelating ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Bromo-4-Hydroxy-5-Methoxybenzonitrile
CAS No.	52805-45-5
Molecular Formula	C9H6BrNO2
Molecular Weight	240.05 g/mol
Synonyms	5-Methoxy-4-hydroxy-3-bromobenzonitrile; 4-Hydroxy-5-methoxy-3-bromobenzonitrile; 3-Bromo-4-hydroxy-5-methoxybenzonitrile; Benzonitrile, 3-bromo-4-hydroxy-5-methoxy-; 3-Bromo-5-methoxy-4-hydroxybenzonitrile; 3-Bromo-4-hydroxy-5-methoxy-benzonitrile
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Hydroxy-5-Methoxybenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.