Description

p-Nitrobenzyl (6R-Trans)-7-Amino-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride is a key pharmaceutical intermediate, specifically a protected derivative of a cephalosporin nucleus. This compound matters for its critical role in the synthesis of advanced β-lactam antibiotics, where it serves as a versatile building block for introducing specific side chains. It is primarily needed by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and production of novel antibacterial agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of advanced cephalosporin antibiotics.
• Antibiotic Research & Development: Used in medicinal chemistry for the design and creation of new β-lactam compounds with improved efficacy or spectrum of activity.
• Process Chemistry: Employed in scale-up and optimization of manufacturing routes for established antibiotic APIs (Active Pharmaceutical Ingredients).
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs (Contract Development and Manufacturing Organizations) producing specialized chemical entities for clients.
• Academic Research: Utilized in university and institutional labs for studying β-lactam synthesis methodologies and structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	p-Nitrobenzyl (6R-Trans)-7-Amino-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride
CAS No.	52602-94-5
Molecular Formula	C16H16N3O5S • HCl
Molecular Weight	389.84 g/mol (Free base: 354.38 g/mol)
Synonyms	(6R,7R)-7-Amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitrobenzyl ester hydrochloride; 7-ACA p-nitrobenzyl ester hydrochloride; 7-Aminocephalosporanic acid p-nitrobenzyl ester hydrochloride; PNZ-7-ACA HCl; 4-Nitrobenzyl 7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride; Cephalosporin C nucleus p-nitrobenzyl ester HCl salt
EINECS	Contact for details

Quality Control

Our p-Nitrobenzyl (6R-Trans)-7-Amino-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride is produced under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.