Description

3-o-Methyl-L-Dopa 4-Glucuronide is a high-purity reference standard and metabolite of the drug L-Dopa, formed via glucuronidation. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in neuroscience and metabolic pathway research.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of L-Dopa and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and excretion profiles of L-Dopa-based therapeutics.
• Bioanalytical Method Development: Serves as a key calibrant and quality control sample in HPLC, LC-MS, and LC-MS/MS assays for precision medicine and therapeutic drug monitoring.
• Neuroscience Research: Applied in preclinical and clinical research to understand the pharmacokinetics of dopaminergic agents used in treating Parkinson's disease.
• Impurity Profiling: Employed to identify and quantify specific glucuronidated impurities or metabolites in active pharmaceutical ingredient (API) batches.
• Regulatory Submissions: Supports regulatory documentation (e.g., for FDA, EMA) by providing definitive characterization data for drug metabolites.

Basic Information

Product Name	3-o-Methyl-L-Dopa 4-Glucuronide
CAS No.	52583-26-3
Molecular Formula	C17H23NO10
Molecular Weight	401.37 g/mol
Synonyms	3-O-Methyl-L-DOPA 4-O-β-D-Glucuronide; 3-OMD 4-Glucuronide; L-Dopa Metabolite Glucuronide; 4-O-β-D-Glucopyranuronosyl-3-O-methyl-L-dopa; (2S)-2-Amino-3-(4-hydroxy-3-methoxyphenyl)-3-oxopropyl β-D-Glucopyranosiduronic Acid; 3-Methoxy-L-tyrosine 4-Glucuronide; 3-OMD-4-Gluc
EINECS	Contact for details

Quality Control

Every batch of 3-o-Methyl-L-Dopa 4-Glucuronide is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing results from advanced chromatographic and spectroscopic methods. Our quality commitment supports compliance with the standards required for pharmaceutical reference materials and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.