Description

n-(Trifluoroacetyl)-o-(Trimethylsilyl)-L-Serine Trimethylsilyl Ester is a sophisticated, multi-protected derivative of the amino acid L-serine, designed for advanced synthetic applications. This compound is critically important for its role as a key chiral building block and protecting group strategy in complex organic synthesis, particularly in peptide and pharmaceutical chemistry. It is primarily needed by research institutions and industrial manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), peptide-based therapeutics, and other high-value fine chemicals where precise stereochemistry and functional group manipulation are paramount.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used for the selective protection of the serine hydroxyl and carboxyl groups during solid-phase and solution-phase peptide synthesis.
• Chemical Research & Development: Serves as a specialized reagent in academic and industrial R&D labs for exploring new synthetic methodologies and constructing complex molecular architectures.
• Protecting Group Strategy: The trifluoroacetyl (TFA) and trimethylsilyl (TMS) groups offer orthogonal protection that can be selectively removed under mild conditions, enabling complex synthetic sequences.
• Bioconjugation & Labeling: Potential use in the synthesis of modified amino acids for bioconjugation or as precursors for fluorescent or isotopic labeling probes.

Basic Information

Product Name	n-(Trifluoroacetyl)-o-(Trimethylsilyl)-L-Serine Trimethylsilyl Ester
CAS No.	52558-12-0
Molecular Formula	C11H20F3NO4Si2
Molecular Weight	335.45 g/mol
Synonyms	L-Serine, N-[(trifluoroacetyl)-O-(trimethylsilyl)-, trimethylsilyl ester; N-Trifluoroacetyl-O-trimethylsilyl-L-serine trimethylsilyl ester; TFA-O-TMS-L-Serine TMS Ester; (2S)-2-[(Trifluoroacetyl)amino]-3-[(trimethylsilyl)oxy]propanoic acid trimethylsilyl ester; N-(Trifluoroacetyl)-O-(trimethylsilyl)-L-serine TMS ester; Protected L-Serine derivative; 52558-12-0
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-o-(Trimethylsilyl)-L-Serine Trimethylsilyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. All materials undergo rigorous analytical testing, including chiral purity verification, to meet the exacting standards of pharmaceutical and advanced chemical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.