Description

Nα-(Trifluoroacetyl)-1-(Trimethylsilyl)-L-Tryptophan Trimethylsilyl Ester is a sophisticated, highly derivatized amino acid building block designed for advanced synthetic chemistry. This compound is critically important for researchers and manufacturers requiring precise, protected intermediates for peptide synthesis and medicinal chemistry applications. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical producers engaged in the development of novel therapeutic peptides and complex organic molecules.

Application

• Advanced Peptide Synthesis: Serves as a key, protected L-tryptophan derivative for solid-phase and solution-phase peptide synthesis, enabling the incorporation of tryptophan residues in complex sequences.
• Medicinal Chemistry & Drug Discovery: Used as a crucial building block in the research and development of peptide-based pharmaceuticals and peptidomimetics.
• Bioconjugation & Probe Development: Acts as a precursor for creating fluorescent or affinity-labeled peptides and proteins for biochemical assays and diagnostic applications.
• Process Chemistry & Scale-up: Employed in the pilot-scale and commercial-scale manufacturing of active pharmaceutical ingredients (APIs) containing modified tryptophan.
• Academic & Industrial Research: Essential for synthetic organic chemists exploring new methodologies and constructing complex natural product analogs.

Basic Information

Product Name	Nα-(Trifluoroacetyl)-1-(Trimethylsilyl)-L-Tryptophan Trimethylsilyl Ester
CAS No.	52558-11-9
Molecular Formula	C21H29F3N2O3Si2
Molecular Weight	482.64 g/mol
Synonyms	N-[(Trifluoroacetyl)-L-tryptophan] bis(trimethylsilyl) ester; 1-(Trimethylsilyl)-N-(trifluoroacetyl)-L-tryptophan trimethylsilyl ester; L-Tryptophan, N-[(trifluoroacetyl)-, bis(trimethylsilyl) ester; Nα-TFA-1-TMS-L-Trp-OTMS; Nα-TFA-L-Trp(1-TMS)-OTMS; TFA-L-Trp(1-TMS)-OTMS; Bis(trimethylsilyl) N-(trifluoroacetyl)-L-tryptophanate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) are available upon request, providing full transparency and traceability for your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.