Description

Thioredoxin is a small, ubiquitous redox protein essential for maintaining the cellular reducing environment and regulating numerous biological processes. Its primary value lies in its ability to catalyze dithiol-disulfide exchange reactions, making it a critical component in research focused on oxidative stress, redox signaling, and protein function. This high-purity biochemical is indispensable for pharmaceutical R&D, academic research in biochemistry and molecular biology, and the development of diagnostic assays and therapeutic applications.

Application

• Biochemical & Pharmaceutical Research: Used as a key reagent in studies of antioxidant defense mechanisms, redox-regulated signaling pathways, and apoptosis.
• Enzyme Activity Studies: Serves as an electron donor for enzymes such as ribonucleotide reductase, methionine sulfoxide reductase, and peroxiredoxins.
• Protein Refolding & Stabilization: Employed in vitro to facilitate the correct disulfide bond formation and refolding of recombinant proteins.
• Diagnostic Kit Development: Integrated into assay systems for detecting oxidative stress markers or evaluating antioxidant capacity.
• Cell Culture & Biotechnology: Used to modulate the redox state in cell culture media to improve cell viability and protein production.
• Therapeutic Agent Research: Investigated for its potential role in developing treatments for diseases related to oxidative stress, including inflammatory and neurodegenerative conditions.

Basic Information

Product Name	Thioredoxin
CAS No.	52500-60-4
Molecular Formula	Contact for details
Molecular Weight	~12 kDa (approx.)
Synonyms	TRX; Trx; TRX1; Thioredoxin-1; ATL-Derived Factor (ADF); Surface-Associated Sulphydryl Protein (SASP); Txn; TrxA; Thioredoxin A
EINECS	Contact for details

Quality Control

Our Thioredoxin is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, activity, and absence of contaminants. We adhere to relevant guidelines for research-grade biochemicals to support your critical applications in discovery and development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive) and light-sensitive. Avoid repeated freeze-thaw cycles. Aliquot contents upon receipt for optimal preservation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (HPLC/MS)	Complies
Purity (SDS-PAGE/HPLC)	> 95%
Biological Activity (Assay)	Contact for details
Endotoxin Level (LAL)	< 1.0 EU/μg (for relevant grades)
Protein Concentration	Specified on COA
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.