Description

Boc-n-Methyl-L-Isoleucine is a protected, non-proteinogenic amino acid derivative essential for advanced peptide synthesis. This high-purity building block is critical for researchers and manufacturers requiring precise control over peptide structure and function. It is primarily utilized in pharmaceutical R&D for the development of novel therapeutic peptides and peptidomimetics, serving the needs of biotechnology, pharmaceutical, and fine chemical industries globally.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of N-methylated isoleucine residues into peptide chains.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Facilitates the creation of metabolically stable and bioavailable peptide mimics by introducing N-methylation.
• Combinatorial Chemistry: Serves as a building block in libraries for high-throughput screening of bioactive compounds.
• Bioconjugation: Can be used in the synthesis of peptide tags and linkers for bioconjugation applications.
• Academic Research: A valuable tool in biochemistry and molecular biology studies investigating protein structure-activity relationships.

Basic Information

Product Name	Boc-n-Methyl-L-Isoleucine
CAS No.	52498-32-5
Molecular Formula	C₁₂H₂₃NO₄
Molecular Weight	245.32 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-N-methyl-L-isoleucine; Boc-N-Me-Ile-OH; (2S,3S)-2-[(tert-Butoxycarbonyl)(methyl)amino]-3-methylpentanoic acid; N-α-Boc-N-methyl-L-isoleucine; Boc-N-methylisoleucine; tert-Butyl N-methyl-N-[(2S,3S)-3-methyl-1-oxo-1-pentyl]carbamate; N-Methyl-N-Boc-L-isoleucine
EINECS	Contact for details

Quality Control

Our Boc-n-Methyl-L-Isoleucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, and is supplied with a corresponding Certificate of Analysis (COA). We adhere to cGMP guidelines where applicable to support our customers in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.