Description

(Des-Asp1,Ile8)-Angiotensin II is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically modified to enhance its receptor selectivity and metabolic stability. This compound is a critical research tool for studying the renin-angiotensin system (RAS), a key regulator of blood pressure, fluid balance, and cardiovascular function. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular disease research, drug discovery, and biochemical assay development.

Application

• Biomedical Research: Used as a selective agonist for studying Angiotensin II receptor subtypes (AT1 and AT2) in cardiovascular and renal physiology.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in high-throughput screening (HTS) for novel antihypertensive and cardiovascular drugs.
• Biochemical Assays: Employed in receptor binding studies, signal transduction pathway analysis, and enzyme activity assays related to the RAS.
• Academic Studies: Facilitates fundamental research into hypertension, heart failure, kidney disease, and other pathologies linked to the angiotensin system.
• Peptide Chemistry Reference: Acts as a model compound in peptide synthesis, modification, and structure-activity relationship (SAR) studies.

Basic Information

Product Name	(Des-Asp1,Ile8)-Angiotensin II
CAS No.	52498-25-6
Molecular Formula	C₄₈H₇₀N₁₂O₁₁
Molecular Weight	999.2 g/mol
Synonyms	Saralasin Acetate; [Sar¹, Ile⁸]-Angiotensin II; 1-Sarcosine-8-Isoleucine Angiotensin II; N-[(S)-1-Carboxy-5-(4-hydroxy-phenyl)-pentyl]glycyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-isoleucine; Ile⁸-Angiotensin II, Sar¹-; Sarcosyl¹-Isoleucine⁸-Angiotensin II
EINECS	Contact for details

Quality Control

Every batch of (Des-Asp1,Ile8)-Angiotensin II is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results from advanced techniques including HPLC, MS, and NMR. Our quality commitment supports reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.