Description

Z-D-Leu-Onp is a protected amino acid derivative, specifically the p-nitrophenyl ester of N-benzyloxycarbonyl-D-leucine, with the CAS registry number 52235-17-3. This compound serves as a crucial building block in peptide synthesis, offering a reactive ester group for efficient coupling reactions under mild conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel peptide-based therapeutics and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Employed as an activated ester for the efficient incorporation of D-leucine residues into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for constructing specific peptide sequences in solution.
• Pharmaceutical Intermediate: Acts as a key raw material in the research and production of peptide drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Facilitates the site-specific attachment of peptides to other molecules, such as proteins, polymers, or surfaces, for diagnostic or therapeutic applications.
• Biochemical Research: Utilized in laboratories for studying enzyme mechanisms, protein-protein interactions, and developing peptide-based probes.
• Production of Custom Peptides: A critical reagent for contract research and manufacturing organizations (CROs/CMOs) specializing in bespoke peptide services.

Basic Information

Product Name	Z-D-Leu-Onp
CAS No.	52235-17-3
Molecular Formula	C20H22N2O6
Molecular Weight	386.40 g/mol
Synonyms	N-Carbobenzoxy-D-leucine p-nitrophenyl ester; N-Cbz-D-leucine 4-nitrophenyl ester; Z-D-Leu-ONp; (R)-2-(((Benzyloxy)carbonyl)amino)-4-methylpentanoic acid 4-nitrophenyl ester; D-Leucine, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester; Cbz-D-Leu-ONp; Nα-Carbobenzyloxy-D-leucine p-nitrophenyl ester; Benzyloxycarbonyl-D-leucine p-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Z-D-Leu-Onp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.