Description

Benzenesulfonyl Fluoride, 4-(Trifluoromethyl)- CAS NO 52201-01-1 is a specialized organofluorine compound featuring a reactive sulfonyl fluoride group and a trifluoromethyl substituent on the benzene ring. This unique structure makes it a valuable high-purity chemical intermediate and building block in advanced synthetic chemistry. It is primarily sought after by pharmaceutical, agrochemical, and material science R&D teams for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs and protease inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that benefit from the stability of the trifluoromethyl group.
• Chemical Biology & Proteomics: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Material Science: Employed as a monomer or cross-linking agent in the synthesis of specialty polymers, coatings, and membranes with enhanced chemical resistance.
• Organic Synthesis Reagent: Acts as a versatile reagent for introducing the benzenesulfonyl moiety or for participating in nucleophilic aromatic substitution (SNAr) reactions.
• Fluorine Chemistry Research: A critical compound for studying the effects of fluorine substitution on reactivity and physical properties in aromatic systems.

Basic Information

Product Name	Benzenesulfonyl Fluoride, 4-(Trifluoromethyl)-
CAS No.	52201-01-1
Molecular Formula	C7H4F4O2S
Molecular Weight	228.17 g/mol
Synonyms	4-(Trifluoromethyl)benzenesulfonyl Fluoride; α,α,α-Trifluoro-p-toluenesulfonyl Fluoride; p-Trifluoromethylbenzenesulfonyl Fluoride; 4-(Trifluoromethyl)phenylsulfonyl Fluoride; TFSF; 4-CF3-PhSO2F; 1-(Trifluoromethyl)-4-(fluorosulfonyl)benzene; 4-(Trifluoromethyl)benzene-1-sulfonyl fluoride
EINECS	Contact for details

Quality Control

Our production of Benzenesulfonyl Fluoride, 4-(Trifluoromethyl)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for demanding applications. All materials are characterized by modern analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.