Description

2-Fluorobenzenesulfonyl Fluoride is a versatile organosulfur and organofluorine compound that serves as a critical building block in advanced chemical synthesis. Its value lies in its dual functional groups, making it a key reagent for introducing the sulfonyl fluoride moiety into target molecules, a valuable handle for SuFEx click chemistry and other transformations. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of sulfonamide-based drugs and bioactive molecules.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced properties.
• SuFEx Click Chemistry: Serves as a reliable electrophile for Sulfur(VI) Fluoride Exchange, enabling rapid and modular assembly of complex molecules.
• Polymer & Material Science: Employed to synthesize functional polymers, coatings, and advanced materials with specific surface properties.
• Chemical Biology Probes: Utilized in activity-based protein profiling (ABPP) and covalent inhibitor design due to its reactivity.
• Cross-Coupling & Functionalization: Acts as a precursor for further derivatization via palladium-catalyzed or other metal-mediated reactions.

Basic Information

Product Name	2-Fluorobenzenesulfonyl Fluoride
CAS No.	52200-99-4
Molecular Formula	C6H4F2O2S
Molecular Weight	178.16 g/mol
Synonyms	o-Fluorobenzenesulfonyl Fluoride; 2-Fluorophenylsulfonyl Fluoride; Benzenesulfonyl fluoride, 2-fluoro-; 1-Fluoro-2-(fluorosulfonyl)benzene; 2-FBSF; o-FBSF; 2-Fluorobenzene-1-sulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 2-Fluorobenzenesulfonyl Fluoride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent hydrolysis and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.