Description

7-Hydroxy Prochlorperazine is a key pharmaceutical intermediate and metabolite of the antipsychotic drug prochlorperazine. This compound is of significant importance for research and development in neuropharmacology and analytical chemistry. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for drug metabolism studies, impurity profiling, and as a reference standard.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity testing of prochlorperazine in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Metabolite Research: Critical for in-vitro and in-vivo drug metabolism and pharmacokinetic (DMPK) studies to understand the biotransformation pathways of prochlorperazine.
• Analytical Method Development: Serves as a crucial calibrant and system suitability compound in HPLC, LC-MS, and other chromatographic methods for quantitative analysis.
• Impurity Synthesis and Control: Employed in the synthesis and qualification of specified impurities for regulatory filing and quality control purposes.
• Pharmacological Research: Used in preclinical studies to investigate the activity and safety profile of prochlorperazine metabolites.

Basic Information

Product Name	7-Hydroxy Prochlorperazine
CAS No.	52172-19-7
Molecular Formula	C₂₀H₂₄ClN₃OS
Molecular Weight	389.94 g/mol
Synonyms	7-Hydroxyprochlorperazine; 2-Chloro-10-[3-(4-hydroxy-1-piperazinyl)propyl]-10H-phenothiazine; Prochlorperazine 7-Hydroxy Metabolite; Prochlorperazine Metabolite II; 1-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-4-piperidinol; 7-OH Prochlorperazine
EINECS	Contact for details

Quality Control

Our 7-Hydroxy Prochlorperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity assay by HPLC, and control of related substances and residual solvents. Certificates of Analysis (COA) detailing all test results are provided to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.