Description

5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 3-[[(Aminocarbonyl)Oxy]Methyl]-7-Methoxy-8-Oxo-7-[(2-Thienylacetyl)Amino]-, Monosodium Salt, cis-(+-)- is a high-purity pharmaceutical intermediate and active ingredient of significant commercial and therapeutic importance. This compound is a key derivative in the synthesis of advanced cephalosporin antibiotics, valued for its role in creating broad-spectrum antibacterial agents. It is essential for manufacturers and research institutions in the pharmaceutical and fine chemical sectors focused on developing and producing next-generation antimicrobial therapies.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of third-generation cephalosporin antibiotics, such as Cefotetan.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a core structural component in the production of finished dosage forms for injectable antibiotics.
• Antibacterial Research & Development: Used in R&D laboratories for developing novel β-lactam compounds with enhanced efficacy against resistant bacterial strains.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to create complex molecules with specific stereochemistry.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.
• Biochemical Studies: Applied in studies investigating the mechanism of action and resistance patterns of β-lactam antibiotics.

Basic Information

Product Name	5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 3-[[(Aminocarbonyl)Oxy]Methyl]-7-Methoxy-8-Oxo-7-[(2-Thienylacetyl)Amino]-, Monosodium Salt, cis-(+-)-
CAS No.	52128-54-8
Molecular Formula	C17H17N4NaO8S2
Molecular Weight	484.45 g/mol
Synonyms	Cefotetan Intermediate; 7-Methoxy-7α-(2-thienylacetamido)-3-[(carbamoyloxy)methyl]-3-cephem-4-carboxylic Acid Sodium Salt; (6R,7S)-7-Methoxy-3-[(carbamoyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Sodium Salt; cis-Cefotetan Synthon; Sodium (6R,7S)-7-Methoxy-3-{[(aminocarbonyl)oxy]methyl}-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Cefotetan Disodium Impurity F (Sodium Salt); 7-Methoxy Cephem Derivative.
EINECS	Contact for details

Quality Control

Our 5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 3-[[(Aminocarbonyl)Oxy]Methyl]-7-Methoxy-8-Oxo-7-[(2-Thienylacetyl)Amino]-, Monosodium Salt, cis-(+-)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and conformity to stringent specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.