Description

Trimetrexate is a potent dihydrofolate reductase (DHFR) inhibitor belonging to the class of quinazoline antifolates. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a selective inhibitor in enzymatic studies to investigate folate metabolism and related pathways.
• Oncology Research: Investigated for its potential anti-proliferative effects in various cancer cell line studies.
• Antimicrobial Agent Development: Explored for its activity against opportunistic infections, such as Pneumocystis carinii pneumonia (PCP).
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Preclinical Development: Used in pharmacological and toxicological studies during early-stage drug discovery.

Basic Information

Product Name	Trimetrexate
CAS No.	52128-35-5
Molecular Formula	C19H23N5O3
Molecular Weight	369.42 g/mol
Synonyms	2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline; TMQ; Trimetrexate Glucuronate (salt form); NSC 352122; CI-898; WR-228258; JB-11; NSC-352122
EINECS	Contact for details

Quality Control

Our Trimetrexate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of related substances. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.