Description

4-Iodo-2-Methylbenzonitrile is a versatile halogenated aromatic nitrile compound, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both an iodine substituent and a nitrile group, makes it a valuable intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily utilized by R&D chemists and process development scientists in the fine chemical and life sciences industries for applications such as cross-coupling reactions and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates, particularly in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the reactivity of the iodine atom for structural diversification.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and material science.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and advanced polymers where the benzonitrile core is functionalized.
• Chemical Biology & Proteomics: Acts as a tagging or labeling reagent in bioconjugation chemistry for probing biological systems.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	4-Iodo-2-Methylbenzonitrile
CAS No.	52107-67-2
Molecular Formula	C8H6IN
Molecular Weight	243.05 g/mol
Synonyms	2-Methyl-4-iodobenzonitrile; 4-Iodo-o-tolunitrile; 2-Cyano-5-iodotoluene; 4-Iodo-2-methylbenzenecarbonitrile; Benzonitrile, 4-iodo-2-methyl-; 52107-67-2; 4-Iodo-2-methyl-benzonitrile
EINECS	Contact for details

Quality Control

Our 4-Iodo-2-Methylbenzonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.