Description

o-Desmethylnaproxen is a key pharmaceutical intermediate and metabolite of the non-steroidal anti-inflammatory drug (NSAID) naproxen. Its primary value lies in enabling critical research and development for new analgesic and anti-inflammatory agents, as well as serving as a reference standard for bioanalytical studies. This compound is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on drug metabolism, pharmacokinetics, and impurity profiling.

Application

• Pharmaceutical Intermediate: Synthesis of novel naproxen derivatives and related anti-inflammatory compounds.
• Metabolite Reference Standard: Used in bioanalytical method development and validation for clinical and preclinical studies of naproxen.
• Impurity Standard: Critical for quality control in naproxen API manufacturing to monitor and control process-related impurities.
• Pharmacological Research: Investigation of metabolic pathways, enzyme activity (CYP450), and structure-activity relationships (SAR).
• Diagnostic Development: Potential use in developing assays for therapeutic drug monitoring (TDM).

Basic Information

Product Name	o-Desmethylnaproxen
CAS No.	52079-10-4
Molecular Formula	C₁₃H₁₄O₃
Molecular Weight	218.25 g/mol
Synonyms	6-Desmethylnaproxen; 6-O-Desmethylnaproxen; 2-(6-Hydroxy-2-naphthyl)propionic Acid; 6-Hydroxy-2-naphthylpropionic Acid; Naproxen Metabolite; ODMN; DMN; 6-Desmethoxynaproxen
EINECS	Contact for details

Quality Control

Our o-Desmethylnaproxen is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.