Description

Antithrombin Iii CAS NO 52014-67-2 is a critical serine protease inhibitor and a key regulatory glycoprotein in the blood coagulation cascade. Its primary function is to inactivate thrombin and other coagulation factors, making it essential for maintaining normal hemostasis and preventing pathological thrombosis. This high-purity biological is indispensable for research, diagnostic, and therapeutic development within the pharmaceutical and biotechnology sectors.

Application

• Therapeutic Agent Development: Serves as a vital active pharmaceutical ingredient (API) or reference standard in the development of anticoagulant and antithrombotic drugs.
• Clinical Diagnostics: Used as a calibrated standard in immunoassays and functional tests to diagnose Antithrombin III deficiency, a hereditary thrombophilia.
• Biochemical Research: Essential for in vitro studies of the coagulation pathway, enzyme kinetics, and structure-function relationships of serine protease inhibitors (serpins).
• Cell Culture & Biotechnology: Employed in specialized cell culture media and processes where precise control of protease activity is required.
• Reference Material: Acts as a high-purity biological reference material for quality control in the production of plasma-derived medicinal products.

Basic Information

Product Name	Antithrombin III
CAS No.	52014-67-2
Molecular Formula	Contact for details
Molecular Weight	~58 kDa (Glycoprotein)
Synonyms	ATIII; Antithrombin III Human; Antithrombin-3; Serpin C1; Heparin Cofactor I; Antithrombin III (Human); AT 3; Antithrombin III Concentrate (Human); Antithrombin III, Plasma-Derived
EINECS	Contact for details

Quality Control

Our Antithrombin III is manufactured and tested under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety, meeting the rigorous standards required for research and development applications. A detailed Certificate of Analysis (COA) documenting purity (by HPLC/SDS-PAGE), functional activity (heparin cofactor assay), and endotoxin levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after use. Handle using appropriate aseptic techniques for biological materials.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (Immunoassay)	Complies
Purity (SDS-PAGE)	≥ 95%
Assay (Functional Activity)	≥ 90% of stated potency
Protein Content	As per COA
Endotoxin	< 1.0 EU/mg
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.