Description

Rifampicin n-Oxide CAS NO 51963-55-4 is a key chemical intermediate and metabolite derived from the antibiotic rifampicin. This compound is of significant importance in pharmaceutical research and development, particularly for studying drug metabolism and for the synthesis of novel derivatives. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical producers engaged in the development of anti-tuberculosis agents and other antimicrobial therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel rifamycin analogs and other specialized antimicrobial agents.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for drug metabolism and pharmacokinetic (DMPK) studies.
• Biochemical Research: Employed in microbiological and enzymatic studies to investigate the mechanism of action and resistance of rifampicin.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the research and development of new antibiotic formulations.
• Quality Control: Acts as an impurity standard for the HPLC analysis and quality assurance of rifampicin bulk drug substances.

Basic Information

Product Name	Rifampicin n-Oxide
CAS No.	51963-55-4
Molecular Formula	C43H58N4O13
Molecular Weight	838.95 g/mol
Synonyms	Rifampicin N-Oxide; Rifampin N-Oxide; Rifamycin AMP N-Oxide; 3-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin S N-Oxide; Rifampicin Metabolite; 5,6,9,17,19,21-Hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-oxidopiperazinyl)formimidoyl]-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate
EINECS	Contact for details

Quality Control

Our Rifampicin n-Oxide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). This product is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.