Description

Thiochrome CAS NO 51827-51-1 is a heterocyclic organic compound derived from thiamine (Vitamin B1) and serves as a key analytical standard and reference material. Its primary commercial value lies in its critical role as a fluorescent derivative for the precise quantification of thiamine in complex matrices. This product is essential for quality control and research laboratories in the pharmaceutical, nutraceutical, and food & beverage industries, where accurate vitamin analysis is paramount for product safety and regulatory compliance.

Application

• HPLC & Fluorescence Detection Standard: Primary use as a reference standard for the quantitative analysis of Vitamin B1 (thiamine) via high-performance liquid chromatography (HPLC) with fluorescence detection.
• Pharmaceutical Quality Control: Used in the assay and purity testing of thiamine hydrochloride and other B1-containing pharmaceutical formulations to ensure potency and meet pharmacopeial standards (USP, EP, BP).
• Food & Nutritional Product Analysis: Critical for the accurate determination of thiamine fortification levels and natural content in foods, infant formula, dietary supplements, and animal feed.
• Clinical & Diagnostic Research: Employed in biochemical research and clinical studies to measure thiamine and its metabolites in biological samples like blood, urine, and tissues.
• Method Development & Validation: Serves as a crucial component in developing, calibrating, and validating new analytical methods for thiamine across various industries.
• Reference Material for Certified Standards: Used by manufacturers of certified reference materials (CRMs) to produce traceable standards for laboratory accreditation and quality assurance programs.

Basic Information

Product Name	Thiochrome
CAS No.	51827-51-1
Molecular Formula	C12H14N4OS
Molecular Weight	262.33 g/mol
Synonyms	Thiochrome; 7,8-Dimethylalloxazine-10-ethanethiol; 2,7-Dimethyl-5H-thiazolo[3,4-a]pyrimidin-5-one; Thiamine quinone; Vitamin B1 quinone; Thiochrome (from thiamine); Alloxazine, 7,8-dimethyl-10-(2-hydroxyethyl)-; Thiochrom
EINECS	257-424-1

Quality Control

Our Thiochrome is manufactured and tested under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for analytical applications. Each lot undergoes comprehensive analysis, including HPLC assay, identification by IR spectroscopy, and control of related substances. A detailed Certificate of Analysis (COA) providing lot-specific data is supplied with every shipment, supporting compliance with GMP, ISO, and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.