Description

[6R-[6Alpha,7Beta(R*)]]-3-(Acetoxymethyl)-7-(Hydroxyphenylacetamido)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a key advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. This compound is critical for the synthesis of semi-synthetic β-lactam antibiotics, offering a foundational structure for developing potent antimicrobial agents. It is primarily required by pharmaceutical manufacturers and research institutions engaged in antibiotic development and production.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Core intermediate for the production of specific cephalosporin-class antibiotics.
• Pharmaceutical Research & Development: Serves as a crucial building block in medicinal chemistry for designing novel antibiotic candidates.
• Process Chemistry & Scale-Up: Used in optimizing synthetic routes for the commercial manufacturing of cephalosporin drugs.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory testing of finished pharmaceutical products.

Basic Information

Product Name	[6R-[6Alpha,7Beta(R*)]]-3-(Acetoxymethyl)-7-(Hydroxyphenylacetamido)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	51818-85-0
Molecular Formula	C19H20N2O7S
Molecular Weight	420.44 g/mol
Synonyms	7-ACA Derivative; 7-[(2-Hydroxyphenyl)acetamido]cephalosporanic Acid; Cephalosporin C Nucleus Derivative; (6R,7R)-7-[(R)-2-Hydroxy-2-phenylacetamido]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-ADCA derivative; 3-Acetoxymethyl-7β-(2-hydroxyphenylacetamido)ceph-3-em-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our [6R-[6Alpha,7Beta(R*)]]-3-(Acetoxymethyl)-7-(Hydroxyphenylacetamido)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting full specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.