Description

Adenosine 5'-o-(1-Thiodiphosphate) is a chemically modified nucleotide analog where one of the non-bridging oxygen atoms in the diphosphate moiety is replaced by sulfur. This compound is a critical biochemical tool, primarily serving as a hydrolysis-resistant analog of adenosine diphosphate (ADP) to study ATP-dependent enzymes and signaling pathways. It is essential for researchers and manufacturers in pharmaceutical development, enzymology, and molecular biology, providing a stable probe for kinase and phosphoryl transfer reactions.

Application

• Enzyme Mechanism Studies: Used as a non-hydrolyzable substrate analog to investigate the kinetics and mechanisms of ATPases, kinases, and other phosphoryltransferases.
• Pharmaceutical Research: Employed in high-throughput screening (HTS) assays to identify and characterize potential inhibitors of ATP-binding proteins involved in disease pathways.
• Structural Biology: Aids in X-ray crystallography and NMR studies to determine the three-dimensional structure of enzyme-ligand complexes.
• Signal Transduction Research: Acts as a stable ligand for purinergic receptors (P2Y receptors) to study nucleotide-mediated cell signaling without rapid degradation.
• Biochemical Reagent Production: Serves as a key raw material or reference standard in the formulation of diagnostic kits and research-grade biochemicals.
• Metabolic Pathway Analysis: Utilized to trace and inhibit specific steps in nucleotide metabolic networks, helping to elucidate cellular energy regulation.

Basic Information

Product Name	Adenosine 5'-o-(1-Thiodiphosphate)
CAS No.	51777-22-1
Molecular Formula	C10H15N5O9P2S
Molecular Weight	467.26 g/mol
Synonyms	Adenosine 5'-(1-Thiodiphosphate); Adenosine-5'-diphosphorothioate; ADP-α-S; ADPαS; Adenosine 5'-[α-thio]diphosphate; 1-Thioadenosine-5'-diphosphate; ADPS; Adenosine 5'-(trihydrogen diphosphate) P'→5'-ester with 1-thioadenosine
EINECS	Contact for details

Quality Control

Every batch of Adenosine 5'-o-(1-Thiodiphosphate) is manufactured and tested under strict quality management systems. We guarantee high purity suitable for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed HPLC purity, NMR identification, and endotoxin levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Endotoxin	< 10 EU/mg (for cell culture grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.