Description

(S)-(+)-5-(Hydroxymethyl)-2-Pyrrolidinone p-Toluenesulfonate is a high-purity chiral intermediate and salt form of a key lactam derivative. This compound matters for its role as a critical building block in the synthesis of complex pharmaceutical molecules, particularly those requiring specific stereochemistry. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure drugs, particularly nucleoside analogs and antiviral agents.
• API Development: Serves as a crucial building block for the research and production of Active Pharmaceutical Ingredients (APIs) targeting neurological and viral diseases.
• Asymmetric Synthesis: Used in catalytic and stoichiometric asymmetric synthesis to introduce the (S)-configured hydroxymethyl pyrrolidinone moiety.
• Pro-drug Synthesis: Utilized in the design and manufacture of pro-drug forms to enhance bioavailability and pharmacokinetic properties.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and agrochemicals.
• Biochemical Research: Acts as a precursor or standard in biochemical research for studying enzyme inhibition and metabolic pathways.

Basic Information

Product Name	(S)-(+)-5-(Hydroxymethyl)-2-Pyrrolidinone p-Toluenesulfonate
CAS No.	51693-17-5
Molecular Formula	C13H17NO5S
Molecular Weight	299.34 g/mol
Synonyms	(S)-5-(Hydroxymethyl)pyrrolidin-2-one 4-methylbenzenesulfonate; (S)-(+)-HMP p-Toluenesulfonate; (S)-5-Hydroxymethyl-2-pyrrolidinone tosylate; (S)-HMPT; L-HMP Tosylate; (S)-5-(Hydroxymethyl)-2-oxopyrrolidine p-toluenesulfonate; (S)-5-Hydroxymethyl-2-pyrrolidone tosylate salt
EINECS	Contact for details

Quality Control

Our (S)-(+)-5-(Hydroxymethyl)-2-Pyrrolidinone p-Toluenesulfonate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.