Description

1-Bromo-4-(Difluoromethylsulfonyl)Benzene is a high-purity, multi-functional aromatic building block characterized by its bromine and difluoromethylsulfonyl substituents. This compound is valued for its unique electronic properties and reactivity, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring sulfonyl and fluorine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoromethylsulfonyl group can contribute to biological activity.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and functional handles.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations for carbon-carbon and carbon-heteroatom bond formation.
• Sulfone Chemistry: Utilized in nucleophilic substitution and addition reactions where the difluoromethylsulfonyl moiety acts as a strong electron-withdrawing group.
• Fluorine Chemistry Exploration: Acts as a valuable reagent for introducing the difluoromethylsulfone (CF2SO2) functional group into target molecules, a moiety of high interest in medicinal chemistry.

Basic Information

Product Name	1-Bromo-4-(Difluoromethylsulfonyl)Benzene
CAS No.	51679-57-3
Molecular Formula	C7H5BrF2O2S
Molecular Weight	271.08 g/mol
Synonyms	4-Bromo-α,α-difluorobenzenemethanesulfonic Acid; p-Bromo-α,α-difluorobenzenemethanesulfonic Acid; 1-Bromo-4-(difluoromethanesulfonyl)benzene; 4-Bromobenzenedifluoromethyl Sulfone; 4-Bromo-α,α-difluorotoluene-ω-sulfone; Benzene, 1-bromo-4-[(difluoromethyl)sulfonyl]-; (4-Bromophenyl)difluoromethyl Sulfone
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(Difluoromethylsulfonyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.