Description

4-Iodophenylacetonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both an iodine substituent and a reactive cyano group, makes it a critical precursor for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as cross-coupling reactions and heterocycle formation.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of compounds with aryl-iodide motifs for further functionalization via palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira).
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the iodophenyl moiety is incorporated into the final active molecule.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine ligands or metal-organic frameworks (MOFs) with tailored properties for catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and photoactive polymers due to its electron-withdrawing characteristics and potential for further derivatization.
• Chemical Biology & Proteomics: Can be used as a building block for synthesizing molecular probes, tags, or affinity labels for studying biological systems.
• General Organic Synthesis: A valuable starting material for preparing various benzo-fused heterocycles, such as indoles, quinolines, and isoquinolines, through cyclization reactions.

Basic Information

Product Name	4-Iodophenylacetonitrile
CAS No.	51628-12-7
Molecular Formula	C8H6IN
Molecular Weight	243.05 g/mol
Synonyms	(4-Iodophenyl)acetonitrile; p-Iodophenylacetonitrile; 4-Iodobenzyl cyanide; 2-(4-Iodophenyl)acetonitrile; (p-Iodophenyl)acetonitrile; 4-Iodobenzeneacetonitrile; α-Cyano-4-iodotoluene
EINECS	Contact for details

Quality Control

Our 4-Iodophenylacetonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. A detailed Certificate of Analysis (COA) is supplied with each batch to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.