Description

1-Azabicyclo[2.2.2]octane-3-carbonitrile is a versatile bicyclic nitrile compound with a rigid, three-dimensional structure, serving as a critical building block in advanced organic synthesis. Its unique scaffold is highly valued for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific steric and electronic properties into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and acting as muscarinic receptor ligands.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where its bicyclic structure contributes to biological activity and stability.
• Ligand and Catalyst Development: Employed as a backbone for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Serves as a monomer or functional additive in the development of polymers with specific thermal or mechanical properties.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and for exploring new chemical spaces in medicinal chemistry programs.

Basic Information

Product Name	1-Azabicyclo[2.2.2]octane-3-carbonitrile
CAS No.	51627-76-0
Molecular Formula	C8H12N2
Molecular Weight	136.20 g/mol
Synonyms	3-Cyanoquinuclidine; Quinuclidine-3-carbonitrile; 1-Azabicyclo[2.2.2]octane-3-carbonitrile; 3-Quinuclidinecarbonitrile; 3-Cyano-1-azabicyclo[2.2.2]octane; 3-Quinuclidyl cyanide; 51627-76-0; NSC 163046
EINECS	Contact for details

Quality Control

Our 1-Azabicyclo[2.2.2]octane-3-carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.