Description

Azetidine, 1-(Trifluoroacetyl)- (9Ci) is a high-value, nitrogen-containing heterocyclic building block featuring a reactive trifluoroacetyl group. This compound is essential for advanced organic synthesis, particularly in the development of novel pharmaceuticals and agrochemicals where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and enzyme inhibitors.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Fluorine Chemistry Building Block: Serves as a versatile precursor for introducing the trifluoroacetyl moiety into more complex molecules, enabling structure-activity relationship (SAR) studies.
• Material Science Research: Potential monomer or modifier in the synthesis of specialty polymers with unique thermal or chemical resistance properties.
• Ligand and Catalyst Development: Can be utilized to create novel nitrogen-donor ligands for transition metal catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Azetidine, 1-(Trifluoroacetyl)- (9Ci)
CAS No.	51599-69-0
Molecular Formula	C5H6F3NO
Molecular Weight	153.10 g/mol
Synonyms	1-(Trifluoroacetyl)azetidine; N-(Trifluoroacetyl)azetidine; Azetidine, N-trifluoroacetyl-; 1-Azetidinyl(trifluoro)methanone; Trifluoroacetic acid azetidide; 2,2,2-Trifluoro-1-(azetidin-1-yl)ethanone
EINECS	Contact for details

Quality Control

Our Azetidine, 1-(Trifluoroacetyl)- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.