Description

trans-(E)-Flupentixol Dihydrochloride CAS NO 51529-02-3 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the thioxanthene class of neuroleptic agents. It is a critical component in the synthesis and formulation of antipsychotic medications, valued for its specific stereochemical configuration which is essential for biological activity. This compound is primarily required by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the development of central nervous system (CNS) therapeutics.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of antipsychotic and neuroleptic medications.
• Pharmaceutical Intermediate for the synthesis of Flupentixol and related thioxanthene derivatives.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Research & Development of novel CNS drugs and pharmacological studies targeting dopamine receptors.
• Formulation Development for creating various dosage forms such as tablets or depot injections.
• Clinical Trial Material supply for investigational new drug (IND) applications.

Basic Information

Product Name	trans-(E)-Flupentixol Dihydrochloride
CAS No.	51529-02-3
Molecular Formula	C₂₃H₂₅F₃N₂OS • 2HCl
Molecular Weight	507.43 g/mol (as free base: 434.52 g/mol)
Synonyms	Flupentixol Dihydrochloride; (E)-Flupentixol 2HCl; Flupentixol HCl; cis(Z)-Flupentixol Dihydrochloride (isomer); α-Flupentixol Dihydrochloride; 2-Trifluoromethyl-9-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propylidene]thioxanthene Dihydrochloride; Emergil; Depixol (as decanoate ester precursor)
EINECS	257-256-6

Quality Control

Our trans-(E)-Flupentixol Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profile. Certificates of Analysis (COA) detailing results from HPLC, NMR, and other pharmacopeial tests are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.