Description

Sulfuryl Fluoride, 4-Nitrophenyl Ester is a specialized organofluorine compound with the CAS registry number 51451-34-4. This chemical serves as a valuable reagent and intermediate in advanced synthetic chemistry, enabling the controlled introduction of sulfuryl fluoride moieties. It is primarily utilized by research and development laboratories, as well as production facilities in the pharmaceutical and agrochemical sectors, for constructing complex molecules and developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring sulfur(VI) fluoride exchange (SuFEx) chemistry.
• Agrochemical Synthesis: Used in the research and production of next-generation pesticides and herbicides, where its functional group offers unique biological activity.
• Chemical Biology Probe: Acts as a reactive handle in the development of activity-based probes for studying enzyme function and protein labeling.
• Polymer Chemistry: Employed as a monomer or cross-linking agent in the development of specialty polymers with specific thermal or chemical resistance properties.
• Material Science Research: Utilized in surface modification and the creation of novel organic-inorganic hybrid materials.
• SuFEx Click Chemistry: A pivotal reagent in sulfur(VI) fluoride exchange reactions, a leading-edge click chemistry platform for bioconjugation and drug discovery.

Basic Information

Product Name	Sulfuryl Fluoride, 4-Nitrophenyl Ester
CAS No.	51451-34-4
Molecular Formula	C6H4FNO5S
Molecular Weight	221.16 g/mol
Synonyms	4-Nitrophenyl Sulfuryl Fluoride; p-Nitrophenyl Sulfuryl Fluoride; Sulfuryl Fluoride p-Nitrophenyl Ester; 4-Nitrophenyl Fluoro Sulfonate; Sulfuryl Fluoride 4-Nitrophenyl Ester; 4-NPSF; 4-Nitrophenyl Sulfurofluoridate
EINECS	Contact for details

Quality Control

Every batch of Sulfuryl Fluoride, 4-Nitrophenyl Ester is produced and analyzed under strict quality management protocols to ensure consistency and reliability for your critical applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity, identity, and impurity profiles. Our commitment to quality assurance supports compliance with the rigorous standards required for research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.