Description

Butedronic Acid CAS NO 51395-42-7 is a high-purity bisphosphonate compound, a class of chemicals known for their strong affinity for bone mineral hydroxyapatite. This property makes it a critical intermediate in the research and development of novel pharmaceuticals targeting bone metabolism disorders. It is essential for manufacturers and R&D laboratories in the pharmaceutical and biotechnology sectors seeking to develop advanced treatments for osteoporosis, Paget's disease, and other conditions involving abnormal bone resorption.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of next-generation bisphosphonate drugs.
• Osteoporosis Research: Used in preclinical and clinical research for developing bone-targeting therapeutic agents.
• Radiopharmaceuticals: Potential as a chelating agent or targeting moiety for bone-seeking diagnostic and therapeutic radiopharmaceuticals.
• Biomedical Research: Utilized in biochemical studies to investigate osteoclast inhibition and bone metabolism pathways.
• Dental Applications: Research into formulations for the treatment of periodontal disease and dental implant coatings.
• Veterinary Medicine: Development of treatments for bone disorders in companion and livestock animals.

Basic Information

Item	Details
Product Name	Butedronic Acid
CAS No.	51395-42-7
Molecular Formula	C5H13NO7P2
Molecular Weight	261.11 g/mol
Synonyms	1-Hydroxy-4-(2-hydroxyethyl)butane-1,1-diyldiphosphonic Acid; 1-Hydroxy-4-(2-hydroxyethyl)butylidene-1,1-bisphosphonic Acid; 4-(2-Hydroxyethyl)-1-hydroxybutylidene-1,1-bisphosphonate; Butedronate; Butedronic Acid Monohydrate; B-4,1-Hydroxyethylidene; (4-Hydroxybutylidene)bisphosphonic Acid
EINECS	Contact for details

Quality Control

Our Butedronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Production adheres to current Good Manufacturing Practice (cGMP) principles where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by advanced analytical techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of atmospheric moisture, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.