Description

5-Hydroxysulfadimidine is a key sulfonamide metabolite and intermediate of significant importance in veterinary and pharmaceutical research. Its primary value lies in its role as a reference standard and a critical building block for the synthesis and analysis of related antimicrobial agents. This compound is essential for researchers and manufacturers in the pharmaceutical, veterinary medicine, and analytical chemistry sectors, particularly for quality control, method development, and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the quantitative and qualitative analysis (e.g., HPLC, LC-MS) of sulfadimidine and its metabolites in drug formulations and biological samples.
• Veterinary Drug Metabolism Studies: A crucial metabolite for investigating the pharmacokinetics, bioavailability, and residue depletion profiles of sulfadimidine in livestock.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a synthetic precursor in the manufacture of advanced sulfonamide-based veterinary therapeutics.
• Analytical Method Development: Employed in laboratories to develop, validate, and calibrate analytical methods for sulfonamide detection in compliance with regulatory guidelines.
• Quality Control & Assurance: Integral for in-process testing and final release testing of sulfadimidine-containing products to ensure potency, purity, and safety.
• Research & Development: Used in academic and industrial R&D for studying sulfonamide chemistry, degradation pathways, and the development of new analytical techniques.

Basic Information

Product Name	5-Hydroxysulfadimidine
CAS No.	51395-19-8
Molecular Formula	C12H14N4O3S
Molecular Weight	294.33 g/mol
Synonyms	5-Hydroxysulfamethazine; N1-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide, 5-hydroxy-; Sulfadimidine 5-Hydroxy Metabolite; 5-Hydroxy-4-[(4,6-dimethyl-2-pyrimidinyl)amino]benzenesulfonamide; 5-OH-SMZ; 5-Hydroxy Sulfamethazine; 5-Hydroxysulfadimidine (Sulfadimidine Impurity C)
EINECS	Contact for details

Quality Control

Our 5-Hydroxysulfadimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for assay and purity, to ensure it meets high-grade specifications suitable for use as a reference material. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.