Description

4,4-Difluoro-3-oxopentanoic acid ethyl ester is a high-value fluorinated β-ketoester building block, essential for introducing difluoroacetyl and related motifs into complex molecules. Its unique structure, featuring both a reactive carbonyl and a fluorinated carbon center, makes it a versatile synthon for constructing heterocycles and fine-tuning molecular properties. This compound is primarily sought by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly for antiviral, anticancer, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used to create novel fluorinated pesticides and herbicides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Material Science Research: Serves as a building block for fluorinated polymers, liquid crystals, and other advanced materials with tailored electronic and surface properties.
• Organic Synthesis Reagent: Employed in Claisen condensations, Michael additions, and cyclization reactions to construct complex, fluorinated heterocyclic scaffolds.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research into the effects of fluorine substitution on chemical reactivity and physical properties.

Basic Information

Product Name	4,4-Difluoro-3-oxopentanoic Acid Ethyl Ester
CAS No.	51368-10-6
Molecular Formula	C7H10F2O3
Molecular Weight	180.15 g/mol
Synonyms	Ethyl 4,4-difluoro-3-oxopentanoate; 4,4-Difluoro-3-oxopentanoic acid ethyl ester; Ethyl 4,4-difluoroacetoacetate; 4,4-Difluoroacetoacetic acid ethyl ester; 1-Ethoxy-4,4-difluoro-1,3-butanedione; DFAAE; Ethyl difluoroacetoacetate
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-3-oxopentanoic acid ethyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.