Description

Antipyrine-3-14C is a carbon-14 radiolabeled derivative of the classic analgesic and antipyretic compound, antipyrine. This isotopically labeled material is essential for conducting advanced metabolic and pharmacokinetic studies, providing researchers with a precise tracer to follow the compound's fate in biological systems. It is a critical tool for pharmaceutical R&D, environmental science, and biochemical research where understanding the absorption, distribution, metabolism, and excretion (ADME) of antipyrine and related compounds is required.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the metabolic pathways, bioavailability, and clearance of antipyrine in preclinical and clinical research.
• Biochemical Research: Employed in enzyme activity assays and studies of cytochrome P450 function, where antipyrine serves as a model substrate.
• Environmental Fate Studies: Tracks the degradation, transformation, and persistence of antipyrine and structurally related compounds in environmental matrices.
• Reference Standard for Analytical Methods: Serves as an internal standard or calibrant in the development and validation of sensitive analytical methods like LC-MS/MS for bioanalysis.
• Toxicological Investigations: Aids in studying the tissue distribution and potential long-term effects of antipyrine exposure.

Basic Information

Product Name	Antipyrine-3-14C
CAS No.	51350-33-5
Molecular Formula	C₁₁H₁₂N₂O * (14C)
Molecular Weight	~188.23 (based on unlabeled form)
Synonyms	1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one-3-14C; Phenazone-3-14C; 2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one-3-14C; Analgesine-3-14C; Sedatine-3-14C; Parodyne-3-14C; [3-14C]Antipyrine; [carbonyl-14C]Antipyrine
EINECS	For unlabeled form: 200-486-8

Quality Control

Every batch of Antipyrine-3-14C is manufactured and analyzed to meet exacting standards for radiochemical purity and specific activity. Our quality assurance includes rigorous testing via HPLC with radiometric detection, TLC, and NMR spectroscopy to confirm identity, purity, and isotopic labeling position. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing the specific activity (mCi/mmol or GBq/mmol), radiochemical purity, chemical purity, and solvent information. We adhere to cGMP principles for the production of materials intended for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) to maintain stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed in a dry environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere. Always follow local regulations for the safe handling and storage of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC, NMR)	Conforms to reference standard
Specific Activity	50-60 mCi/mmol (1.85-2.22 GBq/mmol) or as requested
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (HPLC)	≥ 95%
Solvent (if supplied as solution)	Ethanol, Toluene, or other specified solvent
Concentration (if supplied as solution)	1.0 mCi/mL, 0.1 mCi/mL, or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.