Description

Fluocinonide 22 Methyl Homologue is a synthetic corticosteroid derivative and a key intermediate in the synthesis of high-potency topical glucocorticoids. This compound is of significant value in pharmaceutical research and development, particularly for creating novel anti-inflammatory and immunosuppressive agents. It is primarily required by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on advanced steroid chemistry and dermatological drug development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of Fluocinonide and related high-potency topical corticosteroids.
• Research & Development: Used in medicinal chemistry programs to develop new glucocorticoid receptor agonists with modified pharmacological profiles.
• Reference Standard: Serves as an analytical standard for quality control and impurity profiling in the manufacturing of steroid-based APIs.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for complex steroid molecules.
• Dermatological Formulations: Investigated for potential use in the development of new topical treatments for psoriasis, eczema, and other inflammatory skin conditions.

Basic Information

Product Name	Fluocinonide 22 Methyl Homologue
CAS No.	51333-59-6
Molecular Formula	C27H34F2O7
Molecular Weight	508.55 g/mol
Synonyms	21-Acetoxy-6α,9-difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-3,20-dioxopregna-1,4-diene; 6α,9-Difluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-acetate; Fluocinonide Impurity; Fluocinonide Related Compound; 22-Methyl Fluocinonide Homologue; 6α-Fluoro-11β,16α,17α,21-tetrahydroxy-9α-fluoropregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-acetate
EINECS	Contact for details

Quality Control

Our Fluocinonide 22 Methyl Homologue is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.