Description

5-Pentafluoroethyl-[1,3,4]Thiadiazol-2-Ylamine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of the electron-deficient thiadiazole ring and the highly lipophilic, metabolically stable pentafluoroethyl group, enabling the fine-tuning of molecular properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing novel drug candidates, particularly in areas targeting enzymes and receptors where fluorine substitution is beneficial for potency, metabolic stability, and bioavailability.
• Agrochemical Active Ingredient Development: Serves as a core scaffold for research into new generations of herbicides, fungicides, and insecticides, leveraging the thiadiazole moiety's bioactivity.
• Material Science Precursor: Used in the synthesis of specialty polymers, liquid crystals, or electronic materials where the introduction of fluorine atoms can alter thermal stability, solubility, and dielectric properties.
• Chemical Biology Probe Synthesis: Employed to create tagged or modified molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke research projects and scale-up campaigns requiring this specific fluorinated heterocycle.

Basic Information

Product Name	5-Pentafluoroethyl-[1,3,4]Thiadiazol-2-Ylamine
CAS No.	51314-64-8
Molecular Formula	C4H3F5N3S
Molecular Weight	220.15 g/mol
Synonyms	2-Amino-5-(pentafluoroethyl)-1,3,4-thiadiazole; 5-(Pentafluoroethyl)-1,3,4-thiadiazol-2-amine; 5-(Pentafluoroethyl)-2-amino-1,3,4-thiadiazole; 2-Amino-5-pentafluoroethylthiadiazole; 1,3,4-Thiadiazol-2-amine, 5-(pentafluoroethyl)-; Pentafluoroethylthiadiazolamine
EINECS	Contact for details

Quality Control

Every batch of 5-Pentafluoroethyl-[1,3,4]Thiadiazol-2-Ylamine is produced and analyzed under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specification results is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.